Paving the way for precision medicine v2.0 in intensive care by profiling necroinflammation in biofluids.

Cell Death Differ · 2019 · PMC6294775 · PMID 30201975

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a marginal trendno p-value reported

On the other hand, neutralization of IL-1 signaling using Kineret® (Anakinra; ILRa) in clinical trials resulted only in a marginal trend for increased survival [ 61 ], whereas IL-18 neutralization has not been evaluated in clinical studies so far [ 62 ].

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