Interestingly, genes differentially regulated in daf-2 mutants by PFD-6 displayed a highly significant overlap with those regulated by DAF-16/FOXO but not with those regulated by SKN-1/NRF or SMG-2/UPF1 ( Fig. 6 D–F; Supplemental Fig.
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Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in <i>C. elegans</i>.
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