The degree of mitochondrial DNA methylation in tumor models of glioblastoma and osteosarcoma.

Likewise, a decreasing trend in DNA methylation was observed among the CpG sites within the ND6 , and the HSP and LSP regions from the early stage (Fig. 2 ), which could potentially contribute to the active binding of the mtDNA replication factors to mtDNA, as is the case for POLG where it has been shown that the methylation status of exon 2 is associated with the binding of RNA polymerase II [ 19 ].

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