Human ex vivo 3D bone model recapitulates osteocyte response to metastatic prostate cancer.

Sci Rep · 2018 · PMC6299475 · PMID 30568232

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an increasing trendno p-value reported

3D bone tissues with PCa cells showed an increasing trend in RANKL mRNA levels while OPG remained unchanged. 2D Co-cultures do not recapitulate key expressional changes in osteocytes To highlight the importance of 3D culture, we evaluated the interaction of PCa and osteocytic cells in 2D.

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