Non-invasive biomarkers derived from the extracellular matrix associate with response to immune checkpoint blockade (anti-CTLA-4) in metastatic melanoma patients.

J Immunother Cancer · 2018 · PMC6300009 · PMID 30567561

Europe PMC DOI

hedged sentence

0.0640

closest p · 1.3× alpha

0.0640

boldest claim

The sentences

borderline significantp = 0.064so close (0.05 < p ≤ 0.1)

Interestingly for C1M, although high C1M (Q4) levels were not significantly predictive of OS (Table 2 ), high C1M levels were predictive of PFS by the univariate analysis (HR = 2.13, 95%CI = 1.17–3.88, p = 0.013) and borderline significant with the multivariate analysis (HR = 1.84, 95%CI = 0.97–3.51, p = 0.064) (Additional file 1 : Table S1).

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