General decapping activators target different subsets of inefficiently translated mRNAs.

In support of this interpretation, the up-regulated transcript lists from these strains contain all our previously characterized individual decapping substrates and also exhibited highly significant overlap with the up-regulated transcript lists from dcp1∆ , dcp2∆ , xrn1∆ , and upf1/2/3∆ cells ( Figure 1—figure supplement 2 ).

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