Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved.

Interestingly, all these highly significant pathways that derive from proteins, carbohydrates, and lipids breakdown converge primarily in Acetyl-CoA generation, the key molecule that delivers its acetyl group for oxidation and energy production to the tricarboxylic acid (TCA) cycle (Figure 5B ) and notably at least 22 of the 216 high confidence proteins (Supplementary File 2 ), play key enzymatic roles in the identified pathways, mostly as members of larger enzymatic complexes (marked in red in Figure 5B ).

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