GJA1 (connexin43) is a key regulator of Alzheimer's disease pathogenesis.

Acta Neuropathol Commun · 2018 · PMC6303945 · PMID 30577786

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11 ), in which upregulation of GJA1 , a master regulator of astrocytic gene expression, concomitant with amyloid accumulation during Alzheimer pathogenesis ultimately drives AD clinical and pathological traits as evidenced by highly significant correlation with AD progression and AD GWAS genes (Fig. 2 a-g).

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