Barely Significant
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<i>RASSF1A</i> promoter methylation correlates development, progression, and poor cancer-specific survival of renal cell carcinoma: trial sequential analysis.

Onco Targets Ther · 2019 · PMC6304251 · PMID 30588036

Europe PMCDOI
1
hedged sentence
0.0510
closest p · 1.0× alpha
0.0510
boldest claim

The sentences

borderline significantP =0.051so close (0.05 < p ≤ 0.1)
Huang et al only analyzed whethe RASSF1A promoter methylation was linked to tumor stage (five studies with 252 cases) and grade (four studies with 190 cases), showing that RASSF1A promoter methylation had a borderline significant correlation with tumor stage ( P =0.051) and a significant association with tumor grade ( P =0.001). 49 Our meta-analysis involving more patients suggested that RASSF1A promoter methylation was significantly linked to tumor grade (13 studies with 686 patients with RCC, P <0.001) and clinical stage (8 studies with 463 patients with RCC, P =0.001).

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