Yap1 safeguards mouse embryonic stem cells from excessive apoptosis during differentiation.

Although the positive control (MCl - 1 distal, unmutated) showed an increase in luciferase expression that was just barely not statistically significant by our threshold (p = 0.0613), we argue that these experiments still collectively demonstrate that the Tead-Yap1 interaction is essential for the regulation of these cis- regulatory elements. 8) Figure 2 is not well organized.

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