borderline significantP = 0.050
At this age, there was a borderline significant difference in the E2/E1 ratio with a higher ratio in the NR group [0.76 (0.45–0.95) vs. 0.34 (0.07–0.65); P = 0.050]; however, there were no differences in the E2 concentrations between the two groups; Figures 3A,B .