Phosphoproteomic Analysis of the Amygdala Response to Adolescent Glucocorticoid Exposure Reveals G-Protein Coupled Receptor Kinase 2 as a Target for Reducing Motivation for Alcohol.

Next, volcano plots were created to compare the magnitude of change in phosphopeptide abundance based on the main effect of adolescent CORT exposure ( Figure 2 A) versus the main effect of ethanol self-administration ( Figure 2 B) relative to the −log10 of the p -value from the ANOVA to identify highly significant differences ( y -axis) of large effect size ( x -axis).

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