Moreover, 3C revealed that transcriptional down-regulation is associated with a disruption of RAG locus conformation, with a significant reduction in ASE– Rag2 promoter contacts and a reduction in ASE– Rag1 promoter contacts that fell just short of statistical significance ( P = 0.06; Fig. 7 C ).
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Hierarchical assembly and disassembly of a transcriptionally active RAG locus in CD4<sup>+</sup>CD8<sup>+</sup> thymocytes.
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