Traditional Japanese Herbal Medicine Yokukansan Targets Distinct but Overlapping Mechanisms in Aged Mice and in the 5xFAD Mouse Model of Alzheimer's Disease.

The differences between CC+ and CC− were not significant on any testing day for the control group ( p = 0.60 and p = 0.13, for days 1 and 3, respectively); however, for the YKS group, the difference was highly significant ( p = 0.0011 and p = 0.023, for days 1 and 3, respectively).

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