An Integrative Study of Protein-RNA Condensates Identifies Scaffolding RNAs and Reveals Players in Fragile X-Associated Tremor/Ataxia Syndrome.

To better understand TRA2A-dependent effects, we studied events caused by TRA2A depletion in the absence of CGG aggregates (CGG − TRA2A − ; Figure 7 A): 11 out of 59 CGG + TRA2A + cases are present in CGG − TRA2A − but not in CGG + TRA2A − (CGG − TRA2A − ∩ CGG + TRA2A + ∖CGG + TRA2A − ), which is statistically highly significant.

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