Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response.

There was also a nonsignificant trend toward a decrease in Complex II activity (Fig. 2c ).

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A model that included (Table 2 , model 1) sex, disease severity (total Mayo clinical and endoscopic severity score), and histologic characterization of rectal eosinophils agreed with the model for the full cohort, adding sex with borderline significance.

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