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The efficacy of first-line regimens for Helicobacter pylori eradication in different continents: A systematic review and network meta-analysis protocol.

Medicine (Baltimore) · 2018 · PMC6320060 · PMID 30558078

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an increasing trendno p-value reported
[ 9 ] A recent review alarmed an increasing trend in primary H pylori antibiotic resistance in the world.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.