Among healthy overweight subjects on a weight-reduction program, and receiving vitamin D (83 μg/d) or placebo for 12 months, a borderline significant reduction in TNF-α concentration (−10% in the treatment group versus −3% in the placebo group) was recorded [ 80 ], although this finding was not replicated in subsequent studies [ 75 ].
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Inflammation-Accelerated Senescence and the Cardiovascular System: Mechanisms and Perspectives.
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