Detection of histone H3 K27M mutation and post-translational modifications in pediatric diffuse midline glioma via tissue immunohistochemistry informs diagnosis and clinical outcomes.

In contrast, amongst cases with H3K27me3 signal loss, a significant likelihood of disease progression was observed on log-rank testing ( p = 0.003, Figure 3B ), amongst midline tumors ( p < 0.0043, Figure 3C ), in females ( p = 0.038, Figure 3D ), children less than 5 years of age ( p = 0.017, Figure 3E ), children more than 10 years of age ( p = 0.002, Figure 3F ), and near significance in children with WHO-grade IV tumors ( p = 0.065, Table 3B ).

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