The cirrhotic liver is depleted of docosahexaenoic acid (DHA), a key modulator of NF-κB and TGFβ pathways in hepatic stellate cells.

In agreement with these results, the expression of targets induced at early times post TGFβ treatment, such as SERPINE1/PAI-I or SMAD7 , was not affected by DHA, while delayed targets, such as COL1A1 or αSMA , showed a highly significant decrease in DHA-incubated cells compared to controls (Fig. 5d ).

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