Genome-wide mapping of 8-oxo-7,8-dihydro-2'-deoxyguanosine reveals accumulation of oxidatively-generated damage at DNA replication origins within transcribed long genes of mammalian cells.

Nucleic Acids Res · 2019 · PMC6326803 · PMID 30462294

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highly significantP < 2.2e–16actually significant

Strikingly, as in human cells, we found a highly significant correlation between 8-oxodG and γH2AX signals within the mouse genes (Pearson correlation test, r = 0.9; P < 2.2e–16) (Figure 4F ).

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