The cytotoxic and apoptotic effects of MS17 treatment were accompanied by decrease of E6 and E7 viral oncogene expression in HeLa and CaSki cells across doses but displayed a highly significant downregulation at 9 and 6 μM respectively, proposing that MS17 may also be involved in interfering or associating with the cellular processes that regulate viral gene expression.
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The Curcumin Analogue 1,5-Bis(2-hydroxyphenyl)-1,4-pentadiene-3-one Induces Apoptosis and Downregulates E6 and E7 Oncogene Expression in HPV16 and HPV18-Infected Cervical Cancer Cells.
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