New mtDNA Association Model, MutPred Variant Load, Suggests Individuals With Multiple Mildly Deleterious mtDNA Variants Are More Likely to Suffer From Atherosclerosis.

Overall, we have not observed affected individuals to be more likely to have multiple high scoring non-synonymous variants, however, there was a marginally significant result in the atherosclerosis group (Table 5 ).

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Using this method, we noted a borderline significant difference in atherosclerosis patients that had higher MutPred derived mildly deleterious variant loads.

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