Nitrogen Containing Bisphosphonates Impair the Release of Bone Homeostasis Mediators and Matrix Production by Human Primary Pre-Osteoblasts.

Int J Med Sci · 2019 · PMC6332484 · PMID 30662325

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a positive trendno p-value reported

In detail, after a single administration of both BPs we observed a positive trend in the secretion of TNFα and IL-1β, classically known to inhibit osteoblast differentiation and stimulate bone resorption 34 , 35 .

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