Characterization of cancer genomic heterogeneity by next-generation sequencing advances precision medicine in cancer treatment.

35 , 36 A significant association of high-level heterogeneity and poor survival was evident for lower grade glioma, prostate-, clear cell kidney carcinoma, head and neck-, as well as breast cancers, with borderline significance for melanoma. 18 , 31 , 37 Identification of genomic heterogeneity in hematological malignancy The molecular pathogenesis of acute myeloid leukemia (AML) has been studied by applying cytogenetic analysis tools for more than three decades. 38 Characterization of AML genomes by next-generation sequen

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