Changes in mutation frequency of eight Mendelian inherited disorders in eight pedigree dog populations following introduction of a commercial DNA test.

In six of the ten disorder/breed combinations (prcd-PRA, Labrador Retriever and Cocker Spaniel; PLL, Miniature Bull Terrier; EF, Cavalier King Charles Spaniel; PRA-rcd4, Gordon Setter and Irish Setter) there was a highly significant difference (P<0.1x10 -4 ) between the observed progeny hereditary genotype frequencies and those expected from random mating of parents (born t-2 to t-4 years) with known genotypes, providing unequivocal evidence of selection.

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