A cheap metal for a challenging task: nickel-catalyzed highly diastereo- and enantioselective hydrogenation of tetrasubstituted fluorinated enamides.

pmc-status-qastatus 0 pmc-status-live yes pmc-status-embargo no pmc-status-released yes pmc-prop-open-access yes pmc-prop-olf no pmc-prop-manuscript no pmc-prop-legally-suppressed no pmc-prop-has-pdf yes pmc-prop-has-supplement yes pmc-prop-pdf-only no pmc-prop-suppress-copyright no pmc-prop-is-real-version no pmc-prop-is-scanned-article no pmc-prop-preprint no pmc-prop-in-epmc yes pmc-license-ref CC BY-NC Highly efficient construction of chiral compounds in an environmentally friendly and cost-effective manner is highly significant in organic synthesis and the pharmaceutical industry. 1 Asymmetric hydrogenation of tetrasubstituted alkenes provides ideal access to chiral compounds containing two contiguous stereocenters due to its perfect atom economy and efficiency. 2 Although great effort has been made so far, only a few suc

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