Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue.

Among the thermogenic markers tested, adipose-specific Oct3 KO mice treated with NE displayed a nearly 82-fold increase in Ucp1 , a 5-fold increase in Ppargc1α ( Pgc1α) , and a 3-fold increase in Dio2 , as well as an increasing trend in Hsl and Atgl mRNA expression in ingWAT ( Fig 2I ).

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