Negative Association Between Allopregnanolone and Cerebral Serotonin Transporter Binding in Healthy Women of Fertile Age.

However, the only allopregnanolone association that survived robust regression was the one with SERT binding in the prefrontal cortex (slope = -0.011, SD = 0.003, β = -0.196, p < 0.001), whereas the robust regressions between allopregnanolone and SERT binding in the pallidostriatum and hippocampus were in borderline significance (pallidostriatum; slope = -0.162, SD = 0.083, β = -0.236, p = 0.054, hippocampus; slope = -0.049, SD = 0.027, β = -0.187, p = 0.071).

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The path analysis revealed that allopregnanolone exerted a significant direct effect on frontal cortex SERT binding (standardized estimate -0.321, p = 0.034) and a borderline significant effect on reaction latency (standardized estimate -0.179, p = 0.061).

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