The t 1/2 of NS-PC-S with the larger particle size demonstrated a marginally significant increase compared with NS-PB-S, and the mean days of attaining therapeutically effective plasma concentration increased from 27 days to 32 days.
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Optimization of Extended-Release ZL-004 Nanosuspensions for In Vivo Pharmacokinetic Study to Enhance Low Solubility and Compliance.
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