HDAC3 restrains CD8-lineage genes to maintain a bi-potential state in CD4⁺CD8⁺ thymocytes for CD4-lineage commitment.

One caveat is that IL-4R expression is also significantly higher in HDAC3-deficient DP thymocytes (Figure 5A) and IL-4 leads to enhanced Stat5 activation (although this was not quite statistically significant).

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