Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis.

Acta Neuropathol · 2019 · PMC6338693 · PMID 30225556

Europe PMC DOI

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highly significantp = 6.968E − 8actually significant

Oligomers also induced very low level, but highly significant, toxicity to astrocytes ( p = 6.968E − 8), and this was prevented by TLR4 antagonists (RSLA; p = 7.746E-8, TAK242; p = 8.103E − 8, Fig. 6 cii).

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