Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects.

Nat Commun · 2019 · PMC6341117 · PMID 30664663

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highly significantno p-value reported

When we plotted the ED 50 values for morphine analgesia in WT, S375A, 10S/T-A and 11S/T-A mice against their respective ED 50 values for respiratory depression and constipation we found highly significant correlations (Fig. 4 , Supplementary Table 1 ), suggesting that both opioid effects cannot be uncoupled.

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