HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancer.

Breast Cancer Res · 2019 · PMC6343358 · PMID 30670058

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did not achieve significanceno p-value reported

HIF-2α levels were significantly reduced after PI3K inhibition (ratio pair t-test, P < 0.05).Whilst inhibition of ERK phosphorylation led to a reduction in HIF-2α levels in all experimental repeats, this did not achieve significance (representative of n = 4 experimental repeats).

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