Mrc1 and Tof1 prevent fragility and instability at long CAG repeats by their fork stabilizing function.

Nucleic Acids Res · 2019 · PMC6344861 · PMID 30476303

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highly significantno p-value reported

The role of Mrc1 and Tof1 in maintaining the stability of expanded CAG repeats Our results highlight the importance of the Mrc1 fork protection function in preventing repeat expansions of medium to long CAG tracts that stall replication (85–155 repeats), as we observed a highly significant increase in expansions in mrc1 Δ cells even though contractions were extremely frequent.

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