Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency.

Proc Natl Acad Sci U S A · 2019 · PMC6347702 · PMID 30626647

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highly significantno p-value reported

Here, treatment with empagliflozin led to a highly significant increase in neutrophil numbers, confirming that depletion of 1,5AG can be used to treat neutropenia in these mice ( SI Appendix , Fig.

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just failed to reach statistical significanceno p-value reported

Since this change just failed to reach statistical significance in the experiment shown in Fig. 4 , we performed a second experiment with an independent cohort of younger G6PC3-deficient mice.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.