Association study between KIR polymorphisms and rheumatoid arthritis disease: an updated meta-analysis.

Meta-analysis indicated four markedly significant negative associations of 2DL3 (OR = 0.591, 95% CI = 0.351–0.994; P = 0.047), 2DL5 (OR = 0.716, 95% CI = 0.601–0.853; P < 0.001), 2DS5 (OR = 0.623, 95% CI = 0.393–0.988; P = 0.045), and 3DL3 (OR = 0.324, 95% CI = 0.129–0.814; P = 0.016) with RA susceptibility (Fig. 2 ).

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Although their findings could not support the relation of KIR2DL5 in RA individuals, we observed a highly significant association of KIR2DL5 with risk of RA in our population study, which may impress the disease susceptibility in the same manner as does in SLE.

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