highly significantp < 0⋅005
Thus, at 12 months of age, paired-pulse ratio was lower in TASTPM than wild type mice at both 25 and 50 ms inter-stimulus intervals ( n = 5–8, two-way ANOVA, main effect of genotype p < 0⋅02), while at 18 months of age, the lower paired-pulse ratio was only evident at 25 ms, resulting in a genotype × interval interaction ( p < 0⋅05) and a highly significant Sidak post hoc pairwise comparison between genotype at 25 ms ( p < 0⋅005). 3.3.2 Inhibitory activity is unchanged Although we have concentrated our detailed analysis on glutamatergic activity, we were able to gain an overview of inhibitory activity from the spontaneous activity recorded in the absence of antagonists by utilising CsCl as the internal patch pipette solution.