Programmed genome editing of the omega-1 ribonuclease of the blood fluke, <i>Schistosoma mansoni</i>.

Elife · 2019 · PMC6355194 · PMID 30644357

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highly significantno p-value reported

Reviewer #3: In this highly significant paper, the authors report the first proof of principle for CRISPR/Cas9 mutagenesis and editing of a target gene in a parasitic flatworm of profound medical significance.

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exceedingly significantno p-value reported

This is in exceedingly significant methodological advance in the functional genomics of schistosomes and parasitic flatworms generally.

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