Global Gene Knockout of <i>Kcnip3</i> Enhances Pain Sensitivity and Exacerbates Negative Emotions in Rats.

At the same time, the wild-type rats showed a decreasing trend in sucrose preference post CFA injection (pre: 81.57 ± 4.83, post: 67.43 ± 3.88, p > 0.05, paired t -test), whereas the Kcnip3 -/- rats showed significantly decreased sucrose preference (pre: 63.86 ± 4.11, post: 44.43 ± 5.47, p < 0.05, paired t -test) post CFA injection compared to that prior to CFA injection, suggesting that Kcnip3 -/- rats are more susceptible to depression than wild-type rats.

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In addition, the wild-type showed an increasing trend in the immobility time (pre: 50.86 ± 6.18, post: 68.57 ± 6.48, p > 0.05, paired t -test) post CFA injection compared to that prior to CFA injection, whereas Kcnip3 -/- rats showed significantly increased immobility time (pre: 78.14 ± 7.98, post: 108.00 ± 7.06, p < 0.05, paired t -test), suggesting that Kcnip3 -/- rats are more vulnerable to depression than wild-type rats.

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