This was measured in both groups and found to be reduced in the Cfh −/− mice by 30% compared to C57BL/6 controls, although this just failed to reach statistical significance (p = 0.055).
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Complement factor H regulates retinal development and its absence may establish a footprint for age related macular degeneration.
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0.0550
0.0550
The sentences
Complement is now thought to be important in CNS development 26 and as FH is expressed in the RPE, which is so fundamental to ocular development, its absence here may be significant for retinal maturation and perhaps subsequently for AMD vulnerability.