Dystrophin Deficiency Leads to Genomic Instability in Human Pluripotent Stem Cells via NO Synthase-Induced Oxidative Stress.

In DMD hPSC, all inhibitors showed a decreasing trend in γH2AX foci formation with l -NIO and SM presenting a significant decrease in DMD02 and cDMD, respectively ( Figure S12, Supplementary Table S7 ), but only CAN presented a significant change in all DMD hPSC lines ( Figure 6 b and Figure S12 , for exact values see Supplementary Tables S9 and S10 ).

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