Of the five positively correlated miRNAs, no miRNA data were available for hsa-miR-4324, but the other miRNAs either gave significant HRs (hsa-miR-125b and hsa-miR-381) or showed a trend toward significance (hsa-miR-136 and hsa-miR-145), possibly reflecting the relatively small number of patients in this cohort (Fig. 1 g–j).
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A subgroup of microRNAs defines PTEN-deficient, triple-negative breast cancer patients with poorest prognosis and alterations in RB1, MYC, and Wnt signaling.
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