Previous studies reported that an invasive tumor border was a highly significant predictor of regional LNM and recurrence; however, the results are controversial due to insufficient data and lack of standard evaluation criteria. 33 Thus, the clinical impact of tumor border morphology should be further confirmed in a larger population of submucosal CRC patients.
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Pathological risk factors for lymph node metastasis in patients with submucosal invasive colorectal carcinoma.
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