Exploration of CTCF post-translation modifications uncovers Serine-224 phosphorylation by PLK1 at pericentric regions during the G2/M transition.

Reviewer #2: This manuscript addresses a lingering question in the CTCF field: how can a single protein carry out the multiple functions that are attributed to it, some of which are antagonistic? This is a highly significant study that poses the hypothesis that post-translational modifications may explain the diversity of CTCF roles.

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