close to significanceP = 0.056
When added to additional clinical parameters, dichotomized Afadin remains independent from clinical parameters when using BCSS ( P = 0.015 HR = 2.096, 95% CI 1.157–3.798) ( Supplemental Table S1 ) and LuMFS (nodule: P = 0.005, HR = 3.106, 95% CI 1.404–6.873; size: P = 0.01, HR = 2.888, 95% CI 1.282-6.502) ( Supplemental Table S4 ) and was close to significance when assessing RFS ( P = 0.056 HR = 1.518, 95% CI 0.989–2.329) ( Supplemental Table S2 ).