A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis.

Genes Dev · 2019 · PMC6362817 · PMID 30692207

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highly significantno p-value reported

Notably, we observed a highly significant rescue with genetic ablation of Porcn , which supports further testing of PORCN inhibitors against ZNRF3-deficient human tumors, including ACCs.

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