Nontherapeutic equivalence of a generic product of imipenem-cilastatin is caused more by chemical instability of the active pharmaceutical ingredient (imipenem) than by its substandard amount of cilastatin.

aeruginosa ATCC 27853 (MIC = 1.0 mg/L), a highly significant difference was evident between generic and innovator because the former required twice the dose of the latter to reach bacteriostasis: 251.4 ± 22.1 vs. 131.2 ± 12.2 (P<0.0001; Fig 7B ).

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