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Cytoplasmic Asporin promotes cell migration by regulating TGF-β/Smad2/3 pathway and indicates a poor prognosis in colorectal cancer.

Cell Death Dis · 2019 · PMC6365561 · PMID 30728352

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a decreasing trendno p-value reported
Even though colonoscopy has been widely used in cancer screening and leads to a decreasing trend in CRC mortality, it remains the main cancer burden in developed countries 1 .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.