In this context, the observations that CMA upregulation, through treatment of proximal tubule cells with novel CMA enhancers, upregulates Rab11 expression, corrects Rab11 trafficking and corrects LAMP2A localization in PTCs is highly significant.
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Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells.
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